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Aim. This study reviews the various studies conducted about using stem cells in the treatment of peripheral arterial disorders.

Background. Arterial disorders have affected approximately 8 to 12 million individuals in the united states and is associated with significant mortality morbidity and mortality. Critical limb ischemia (CLI) is the end stage of lower extremity peripheral arterial disease. The mainstay of therapy for severe ischemia is endovascular revascularization with the aim of improving blood flow to the affected limb. However, for 20 to 30 percent of patients with CLI that are not considered for endovascular revascularization stem cell therapy may be useful.

Method. In this review, after the searching out databases and electronic resources the latest and most relevant studies about the use of stem cell therapy were considered.

Findings. The studies have shown that stem cell therapy is useful for peripheral arterial disorders, especially for those patients who are not candidate for surgical treatment. It has been found that this method is more effective for patients with Buerger's disease than those with peripheral arterial disorders, and that intramuscular injection method is preferred to intra-arterial injection method. It has been shown that using stem cells derived from bone marrow is more effective and less costly than stem cells derived from peripheral blood. This method is not associated with significant side effects and well tolerated by patient.

Conclusion. Stem cell therapy is an effective and promising treatment strategy, especially in patients who are not candidate for endovascular surgery.

 

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Abstract
Aim. The aim of this study was to determine the relationship between quality of life and demographic characteristics of people with angina pectoris in Shohada Hospital in Qaen city, Iran in 2014.
Backgrounds. Cardiovascular disease is the most common cause of death in most countries around the world, including Iran, and also, it is the most important cause of disability. Cardiovascular disease is one of the most preventable non-communicable diseases. Quality of life in heart disease is associated with inappropriate changes, as several factors contribute to improving the quality of life of these patients..
Method. This cross-sectional correlational study was conducted on 240 individuals with angina pectoris in the CCU and Post-CCU wards of Shohada Qaen Hospital, Qaen, Iran, from April to December 2014. The sample were recruites by census method and the SF-36 tool was used to assess the quality of life. The questionnaire was completed by interviewing patients. Data were analyzed in SPSS-20, using Mann-Whitney and Kruskal-Wallis tests.
Findings. The mean score of total quality of life was 61.74±22.49, indicating good quality of life. The findings showed that the age was significantly related to the role disorder due to emotional health (P=0.034), energy/ fatigue (P=0.001) and general health (P=0.004) domains of quality of life. The gender was significantly related to the role disorder due to emotional health (P=0.008), energy/ fatigue (P=0.01), social function (P=0.003) and general health (P=0.04). The marital status was significantly related to the physical function (P=0.032), and energy/ fatigue (P=0.04). Finally, a statistically significant relationship was found of education level with energy/ fatigue (P=0.007) and general health (P=0.001).
Conclusion. The use of appropriate care approaches, including educational programs is suggested for people with angina pectoris in order to improve their quality of life.