Abstract
Aim. This study reviews the role of vitamin E in cardiovascular diseases.
Background. Cardiovascular diseases are among the most common health-related problems, and the number of the patients with cardiovascular diseases increases each year. Long-term manifestations of cardiovascular disease bears a lot of cost to the family and society.
Method. This review study was conducted by searching out the related literature in the databases Google Scholar, PubMed, PMC, Springer, and Elsevier, for papers published from 2014 to 2018. Initially, a total of 72 articles were found and the number of articles was reduced to 42 by removing duplicates and articles that were only accessible as abstract. Finally, a review by 21 articles was carried out.
Findings. α-Tocopherol is the most common form of vitamin E in human tissues. Increased oxidative stress is an important mediator of endothelial injury in hypertension pathology, associated with increased oxidant protein production, such as hydrogen peroxide super oxidation, decreased nitric oxide synthesis, and decreased biological capacity of antioxidants. Oxidative stress may lead to endothelial dysfunction, inflammation, hypertrophy, fibrosis, and angiogenesis associated with hypertensive vascular changes. Vitamin E deficiency can provide a constraint for micro ribonucleic acids (miRNAs) networks, and this may lead to the progression of atherosclerosis. Vitamin E deficiency causes adverse effects in cardiovascular systems. However, the effect of its use in the treatment of diseases is still not fully understood.
Discussion. A good amount of Vitamin E should be provided and it should be replaced before the complications occur.

Abstract
Aim. The aim of this study was to determine the attitudes of intensive care unit nurses towards communicating with unconscious or conscious intubated patients unable to speak.
Background. Communication is one of the most important tools in patient care and is more important in intensive care units because many patients are unable to communicate verbally due to illness or treatment.
Methods. This descriptive cross-sectional study was conducted on 174 nurses working in intensive care units. They were selected by convenience sampling method. Data were collected by a researcher-made questionnaire through self-report. This questionnaire had two sections of views on communication with unconscious or conscious intubated patients unable to talk and factors related to non-communication with these patients which was completed either in paper or electronic form. The data were analyzed in SPSS version 26 using descriptive statistics and Pearson correlation.
Findings. The results showed that the majority of the studied units (94.3 percent) had a positive attitude towards communicating with patients with speech disabilities admitted to intensive care units. It was also found that large number of patients, nurse's reluctance to work in intensive care units, loading of unprofessional tasks, psychological fatigue, and no mastery in communicative skills are more associated with communicating with this group of patients.
Conclusion. According to the positive attitude of nurses towards communicating with unconscious or conscious intubated patients unable to speak, this positive attitude can be used to improve nurses' communication performance. In addition, it is necessary to improve the quality and quantity of communication with patients with speech problems through management measures to control some factors related to communicating with patients with speech impediments.