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Abstract
Aim. The purpose of this study is to review new achievements in prevention and treatment of venous thromboembolism (VTE) in orthopedic surgeries.
Background.
Method. This is a comprehensive review of literature published between 1998-2017 about prevention and treatment of VTE in orthopedic surgeries that was conducted through searching scientific databases and search engines Ovid, Science Direct, Medline, Google Scholar, and PubMed using the English and Persian forms of the words Apixaban, Dabigatran, Heparin, orthopedic procedures, venous thromboembolism, and Fondaparinux. In total, 35 English papers and 10 Persian papers were found, out of which 25 papers were included in the review.
Findings. The risk of VTE is increased considerably during orthopedic surgeries. It is associated with important morbidities and also can increase mortality rate. Without prophylaxis, there is a noticeably increased risk of both venous and pulmonary embolism. Choosing a prophylactic pharmacologic agent depends on its efficacy and safety and also, on the presence of comorbidities and patient preferences.
Conclusion. The features of primary preferred primary prophylactic method is easy management safety, effectiveness with limited or no need for laboratory observation, and cost effectiveness. The use of prophylactic anticoagulation in patient undergoing major orthopedic surgeries considerably reduces the risk of VTE, but does not completely exclude it.